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Medicine · SHA-256 / FIPS 180-4

SHA-256 / FIPS 180-4 for clinical AI workflows

SHA-256 / FIPS 180-4 in clinical AI workflows: what compliance requires, who asks for evidence, and the records to keep.

Legal forceMandatory for federal agencies needing an approved hash; widely used voluntarily
Applies from4 Aug 2015
SectorMedicine
Checked21 Oct 2026

01 / The rule

What SHA-256 / FIPS 180-4 requires

Federal agencies and vendors implementing approved hash functions; used worldwide in signatures, integrity checks and provenance records.

  1. 01Use a FIPS-approved hash algorithm (SHA-2 family; SHA-3 is in FIPS 202) where federal rules require one.
  2. 02Compute digests exactly as specified, including message padding and parsing into 512-bit blocks for SHA-256.
  3. 03Do not use SHA-1 for new applications; NIST plans to remove it by December 31, 2030.
  4. 04Use CAVP-validated implementations inside validated cryptographic modules for federal systems.

02 / In this sector

In a clinical AI workflow

Hashing model weights, datasets, prompts and outputs with SHA-256 lets a third party check that an AI artifact is the one that was tested. The standard says nothing about AI specifically.

Usually asked by

Clinical committees and health system AI governance.

Named alongside

HHS §1557 · HIPAA · FDA PCCP.

Sector pagePlanisphere for medicine

03 / Records

Records to keep

  1. 01Recorded SHA-256 digests of released artifacts
  2. 02CAVP algorithm validation certificate for the implementation
  3. 03Signed manifests or Merkle roots binding digests together

Optional evidence · where Planisphere fits

Keep a record anyone can check

When your team meets a duty, Planisphere can seal the event it reports as a receipt.

01 · Your teamRecord the event

A disclosure shown, a review signed, a model change approved: the event your system reports.

02 · PlanisphereSeal it

The event becomes a sealed receipt, dated and attributed to whoever is signed in.

03 · AnyoneCheck it

Paste the receipt into Verify. No account or key.

A record supports your compliance evidence process. It is not a legal finding or a certification. Systems that call Planisphere's gate API can also hold or refuse an action before it runs.

SOURCES

Go back to the source

RELATED

Related: SHA-256 / FIPS 180-4: the full guide · SHA-256 / FIPS 180-4 for defense · SHA-256 / FIPS 180-4 for law · SHA-256 / FIPS 180-4 for education