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Medicine · NIST SP 800-53 Rev. 5

NIST SP 800-53 Rev. 5 for clinical AI workflows

NIST SP 800-53 Rev. 5 in clinical AI workflows: what compliance requires, who asks for evidence, and the records to keep.

Legal forceMandatory for federal information systems; binding on contractors through FedRAMP and contracts
Applies from23 Sep 2020
SectorMedicine
Checked21 Oct 2026

01 / The rule

What NIST SP 800-53 Rev. 5 requires

Federal agencies and the contractors and cloud providers operating systems on their behalf; widely adopted voluntarily elsewhere.

  1. 01Select a control baseline (from SP 800-53B) based on system impact level, then tailor it.
  2. 02Implement and document controls across 20 families, including access control, audit, configuration and supply chain risk (SR).
  3. 03Assess control effectiveness, using SP 800-53A procedures, before authorization to operate.
  4. 04Continuously monitor controls and update the system security and privacy plans.
  5. 05Under Release 5.2.0, verify software update integrity and test, deploy and manage patches (SA-24, SI-02(07), SI-07(12)).

02 / In this sector

In a clinical AI workflow

Applies to AI systems as to any system. NIST is drafting AI-specific overlays on these controls, but none has reached a numbered public draft yet.

Usually asked by

Clinical committees and health system AI governance.

Named alongside

HHS §1557 · HIPAA · FDA PCCP.

Sector pagePlanisphere for medicine

03 / Records

Records to keep

  1. 01System security and privacy plan with tailored control baseline
  2. 02Security assessment report and plan of action and milestones
  3. 03Authorization to operate decision
  4. 04Continuous monitoring and audit log records

Optional evidence · where Planisphere fits

Keep a record anyone can check

When your team meets a duty, Planisphere can seal the event it reports as a receipt.

01 · Your teamRecord the event

A disclosure shown, a review signed, a model change approved: the event your system reports.

02 · PlanisphereSeal it

The event becomes a sealed receipt, dated and attributed to whoever is signed in.

03 · AnyoneCheck it

Paste the receipt into Verify. No account or key.

A record supports your compliance evidence process. It is not a legal finding or a certification. Systems that call Planisphere's gate API can also hold or refuse an action before it runs.

SOURCES

Go back to the source

RELATED

Related: NIST SP 800-53 Rev. 5: the full guide · NIST SP 800-53 Rev. 5 for defense · NIST SP 800-53 Rev. 5 for law · NIST SP 800-53 Rev. 5 for education